Dipeptiven

•  Dipeptiven is indicated as part of an intravenous parenteral nutrition regimen as a supplement to amino acid solutions or an amino acid containing infusion regimen, e.g. in patients in hypercatabolic and/or hypermetabolic states

Dipeptiven 20%, 50ml and 100ml glass bottles

• Depends on severity of the catabolic state & on amino acid requirement
• 1.5 -2.5 ml/kg body wt. (=100 to 175 ml Dipeptiven for a patient of 70 kg body weight)
• Rate of infusion should not exceed 0.1g amino acids/kg body wt./hr
• Duration of use should not exceed 3 weeks
• Not designed for direct administration
• Should be mixed with a compatible amino acid carrier solution or an amino acid containing infusion regimen

• 2g amio acids/kg body wt. should not be exceeded in PN
• Proportion of amino acid supplied through Dipeptiven should not exceed ~30% of total amino acid
• 2.5ml or 0.5g N(2)-L-alanyl-L-glutamine of Dipeptiven per kg body weight.

• May improve survival rate and reduce 6-month mortality rate
• Reduced length of hospital stay
• Reduced infectious complications
• Reduced rates of hyperglycemia
• Gut integrity maintained
• Improved nitrogen balance
• Strengthened immune defense

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31.Glutamine product information binder. Dipeptiven®, Glamin®: parenteral nutrition.

Version 2, January 2006. Fresenius Kabi, data on file.

32.Dipeptiven (L-alanyl-L-glutamine). Summary of product characteristics

Characteristics Dipeptiven AA gms 20 Total Nitrogen (g/l/pack) 3.2 Total Kcals/100ml 80 Osmolarity (mosmol/L) 921 Infusion Rate 8 drops/min, should not exceed 0.1g AA/kg/hr Max.Dosage (ml/kg/day) 2.5 Shelf life (months) 24 Route of Adm Central/peripheral