SMOFlipid

​Lipid emulsion for parenteral nutrition containing four different types of oils.

  1. The unique, well-balanced lipid emulsion with purified natural fish oil
  2. 30% soybean oil as reliable source of essential fatty acids
  3. 30% medium-chain triglycerides (MCT) as source of rapidly available energy
  4. 25% olive oil for supply of monounsaturated fatty acids, especially oleic acid
  5. 15% fish oil provides ω-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)
  6. Additionally vitamin E (approximately 200 mg a-tocopherol/L)
  7. Fatty acid pattern with respect to saturated fatty acids, monounsaturated fatty acids, and essential fatty acids is similar to human milk
  8. Extensive compatibility and stability data are available with a wide range of admixtures

  • SMOFlipid is indicated in patients who needs intravenous nutrition to supply energy, essential fatty acids and omega-3 fatty acids

20% SMOF, (100ml, 250ml, 500ml) glass bottle,

  • Adult: Standard dose: 1.0 – 2.0 g fat/kg body wt
  • Neonates & infants: 0.5 – 1.0g fat/kg body wt/day, Followed by: 0.5 -1.0 g fat/kg body wt/day up to 3.0 g fat/kg body wt/day
  • Children: It is recommended not to exceed a daily dose of 3 g fat/kg body wt/day.  Daily dose gradually increased during first week

  • Positive impact on liver cell function and integrity
  • Favourable immune and inflammatory response
  • For adequate antioxidative protection
  • To prevent antioxidant depletion
  • Reduced length of hospital stay

  1. Piper SN et al. EJA 2009; 26: 1076-1082
  2. Antebi H et al. JPEN 2004; 28:142 – 148
  3. Schade I et al. Crit Care 2008; 12 (Suppl 2) S56–S57
  4. Grimm H et al. EJN 2006; 45:55–60
  5. Mertes N et al Ann. Nutr. Metab. 2006; 50:253-259
  6. Tomsits E et al. Journal of Pediatric Gastroenterology & Nutrition 2010; 51:514-52
  7. Klek S et al. Clin Nutr. 2012; epub ahead of print (http://dx.doi.org/10.1016/j.clnu.2012.06.011

Characteristics:

SMOFlipid 20%

Soybean oil, refined:     

60g

Triglycerides, medium-chain:     

60g

Olive oil, refinded:          

50g

Fish oil, rich in omega-3-acids:   

30g

Esential fatty acids

21%

Total Energy (kcal/l)

2000

pH-Value

approx. 8

Osmolality

approx. 387 mosm/kg

Osmolarity

290mosm/l

w-6/w-3 fatty acid ratio

2.5:1

Shelf life (months)

24

Route of Adm

peripheral/central